VAMP5 Gene Summary [Human]
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of vesicles and cell membranes. The VAMP5 gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family and the SNARE superfamily. This VAMP family member may participate in vesicle trafficking events that are associated with myogenesis. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | VAMP5 |
| Official Name | vesicle associated membrane protein 5 [Source:HGNC Symbol;Acc:HGNC:12646] |
| Ensembl ID | ENSG00000168899 |
| Bio databases IDs | |
| Aliases | vesicle associated membrane protein 5, myobrevin |
| Synonyms | AF119384, Camp, vesicle-associated membrane protein 5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human VAMP5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- SNARE motif
- Synaptobrevin
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic scoliosis
- coronary artery disease
- myocardial infarction
- pervasive developmental disorder
role in cell
- fusion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytoplasmic vesicle membrane
- Cytoplasm
- cell surface
- perinuclear region
- intracellular membranes
- cellular membrane
- vesicles
- intercellular junctions
- trans Golgi network
- late endosomes
- perinuclear vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human VAMP5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- skeletal muscle tissue development
- cell differentiation
- Golgi to plasma membrane protein transport
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle membrane
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- late endosome
- intercalated disc
- Golgi apparatus
- organelle membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding