NAPB Gene Summary [Human]
This gene encodes a member of the soluble N-ethyl-maleimide-sensitive fusion attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. This gene encodes the SNAP beta isoform which has been shown to be preferentially expressed in brain tissue. The encoded protein also interacts with the GluR2 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit C-terminus and may play a role as a chaperone in the molecular processing of the AMPA receptor. [provided by RefSeq, Mar 2017]
Details
| Type | Protein Coding |
| Official Symbol | NAPB |
| Official Name | NSF attachment protein beta [Source:HGNC Symbol;Acc:HGNC:15751] |
| Ensembl ID | ENSG00000125814 |
| Bio databases IDs | |
| Aliases | NSF attachment protein beta, beta soluble NSF attachment protein |
| Synonyms | Brp14, b-SNAP, DEE107, E161, I47, N-ethylmaleimide sensitive fusion protein attachment protein beta, N-ethylmaleimide sensitive fusion protein attachment protein β, NSF attachment protein beta, NSF attachment protein β, SNAPB, SNAP-BETA, SNAP-β, SNARE, β-snap |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NAPB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family
- protein binding
- transporter
- syntaxin binding
- Soluble NSF attachment protein, SNAP
Pathways
Biological processes and signaling networks where the NAPB gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- glutaminergic synapse
- presynaptic regions
- postsynaptic region
- intracellular membranes
- Plasma Membrane
- presynaptic membrane
- synaptic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NAPB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of synaptic vesicle priming
- SNARE complex disassembly
- intracellular protein transport
- synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- synaptobrevin 2-SNAP-25-syntaxin-1a complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- syntaxin binding
- soluble NSF attachment protein activity