ZDHHC8 Gene Summary [Human]
This gene encodes a four transmembrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein may function as a palmitoyltransferase. Defects in this gene may be associated with a susceptibility to schizophrenia. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromosome 22.[provided by RefSeq, May 2010]
Details
| Type | Protein Coding |
| Official Symbol | ZDHHC8 |
| Official Name | zinc finger DHHC-type palmitoyltransferase 8 [Source:HGNC Symbol;Acc:HGNC:18474] |
| Ensembl ID | ENSG00000099904 |
| Bio databases IDs | |
| Aliases | zinc finger DHHC-type palmitoyltransferase 8, Zinc finger protein 378 |
| Synonyms | D16H22S1738E, DHHC-8, E330009O14RIK, LOC100364821, OP53C05, ZDHHCL1, zinc finger, DHHC domain containing 8, zinc finger DHHC-type palmitoyltransferase 8, ZNF378 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZDHHC8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- palmitoyltransferase
- PDZ domain ligand
- protein-cysteine S-palmitoleyltransferase
- DHHC palmitoyltransferase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- lung adenocarcinoma
- lung adenocarcinoma formation
role in cell
- expression in
- phosphorylation in
- growth
- growth in
- arborization
- abnormal morphology
- palmitoylation in
- accumulation in
- arborization in
- long term synaptic depression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- perinuclear region
- postsynaptic region
- cellular membrane
- Golgi Apparatus
- Mitochondria
- cytosol
- Golgi membrane
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZDHHC8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- high-density lipoprotein particle assembly
- locomotory behavior
- peptidyl-L-cysteine S-palmitoylation
- positive regulation of cholesterol efflux
- protein palmitoylation
Cellular Component
Where in the cell the gene product is active
- mitochondrial membrane
- cytosol
- Golgi apparatus
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- protein-cysteine S-palmitoleyltransferase activity
- palmitoyltransferase activity