DLX2 Gene Summary [Human]
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | DLX2 |
| Official Name | distal-less homeobox 2 [Source:HGNC Symbol;Acc:HGNC:2915] |
| Ensembl ID | ENSG00000115844 |
| Bio databases IDs | |
| Aliases | distal-less homeobox 2 |
| Synonyms | DII A, distal-less homeobox 2, DLX-5, TES-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DLX2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- Homeobox protein distal-less-like N terminal
- chromatin binding
- protein binding
- sequence-specific DNA binding
- single-stranded RNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- homeodomain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- meteorism
- hypoperistalsis
- androgenic alopecia
- dyspnea
- cyanosis
role in cell
- activation in
- expression in
- signaling in
- apoptosis
- growth
- survival
- migration
- quantity
- loss
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DLX2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- embryo development
- oligodendrocyte differentiation
- forebrain neuron differentiation
- subpallium development
- embryonic cranial skeleton morphogenesis
- positive regulation of cell differentiation
- branching morphogenesis of a nerve
- hippocampus development
- odontogenesis of dentin-containing tooth
- brain development
- negative regulation of photoreceptor cell differentiation
- negative regulation of Notch signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- olfactory bulb development
- cerebral cortex GABAergic interneuron fate commitment
- proximal/distal pattern formation
- negative regulation of oligodendrocyte differentiation
- negative regulation of transcription from RNA polymerase II promoter
- Notch signaling pathway
- cell differentiation
- cartilage development
- neuroblast differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- single-stranded RNA binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity