DHRS2 Gene Summary [Human]
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members of this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative promoter use and alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Details
| Type | Processed Transcript |
| Official Symbol | DHRS2 |
| Official Name | dehydrogenase/reductase 2 [Source:HGNC Symbol;Acc:HGNC:18349] |
| Ensembl ID | ENSG00000100867 |
| Bio databases IDs | |
| Aliases | dehydrogenase/reductase 2, short chain dehydrogenase/reductase family 25C, member 1 |
| Synonyms | 5430405K24Rik, dehydrogenase/reductase 2, Dehydrogenase/reductase 2 in primates, dehydrogenase/reductase member 2, HEP27, LOC679180, SDR25C1, short CHAIN ALCOHOL DEHYDROGENASE family member |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DHRS2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- polyketide synthase keto reductase domain
- Rossmann-fold NAD(P)(+)-binding proteins
- sepiapterin reductase
- KR domain
- CH-OH group:NAD or NADP oxidoreductase
- pteridine reductase
- enzyme
- protein binding
- Enoyl-(Acyl carrier protein) reductase
- short chain dehydrogenase
- 3-oxoacyl-(acyl-carrier-protein) reductase, putative
- carbonyl reductase (NADPH)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cervical cancer
- epithelial cancer
- cervical small cell carcinoma
- extrapulmonary small cell cancer
- epithelial uterine cancer
- adenoid cystic carcinoma
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
regulates
- TP53
- 1-phenyl-1,2-propanedione
- 2,3-heptanedione
- 3,4-hexanedione
role in cell
- replication in
- degradation in
- apoptosis
- response by
- aggregation in
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Mitochondria
- nucleoplasm
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DHRS2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of apoptotic process
- negative regulation of cell proliferation
- myeloid dendritic cell differentiation
- cellular response to oxidative stress
- electron transport chain
- C21-steroid hormone metabolic process
- response to toxin
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nucleus
- cytoplasm
- mitochondrial matrix
- mitochondrion
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- carbonyl reductase (NADPH) activity
- protein binding
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor