PER3 Gene Summary [Human]
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been linked to sleep disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2014]
Details
| Type | Protein Coding |
| Official Symbol | PER3 |
| Official Name | period circadian regulator 3 [Source:HGNC Symbol;Acc:HGNC:8847] |
| Ensembl ID | ENSG00000049246 |
| Bio databases IDs | |
| Aliases | period circadian regulator 3 |
| Synonyms | 2810049O06RIK, FASPS3, GIG13, mPer3, period3, period circadian clock 3, period circadian regulator 3, rper3, XSG3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PER3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Period protein 2/3C-terminal region
- ubiquitin protein ligase binding
- kinase binding
- PAS domain
- PAS
- protein binding
- PAS fold
Pathways
Biological processes and signaling networks where the PER3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection by HIV-1
- osteoarthritis
- COVID-19
- familial advanced sleep phase syndrome type 3
- cleft lip
- Crohn disease
- behavioral deficit
- breast adenocarcinoma
role in cell
- expression in
- differentiation
- cell cycle progression
- adipogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PER3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- circadian regulation of gene expression
- regulation of circadian sleep/wake cycle, sleep
- entrainment of circadian clock by photoperiod
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- transcription corepressor binding
- protein binding
- ubiquitin protein ligase binding
- transcription regulatory region sequence-specific DNA binding
- kinase binding