BRMS1L Gene Summary [Human]
The protein encoded by this gene shows sequence similarity to the human breast carcinoma metastasis suppressor (BRMS1) protein and the mammalian Sds3 (suppressor of defective silencing 3) proteins. This protein is a component of the mSin3a family of histone deacetylase complexes (HDAC). [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | BRMS1L |
| Official Name | BRMS1 like transcriptional repressor [Source:HGNC Symbol;Acc:HGNC:20512] |
| Ensembl ID | ENSG00000100916 |
| Bio databases IDs | |
| Aliases | BRMS1 like transcriptional repressor |
| Synonyms | 0710008O11Rik, breast cancer metastasis-suppressor 1-like, BRMS1, BRMS1 like transcriptional repressor, D12Ertd407e, LOC100039915, p40 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BRMS1L often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BRMS1L gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transforming growth factor beta receptor signaling pathway
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- Sin3-type complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone deacetylase binding