NFATC4 Gene Summary [Human]
This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Details
| Type | Processed Transcript |
| Official Symbol | NFATC4 |
| Official Name | nuclear factor of activated T cells 4 [Source:HGNC Symbol;Acc:HGNC:7778] |
| Ensembl ID | ENSG00000100968 |
| Bio databases IDs | |
| Aliases | nuclear factor of activated T cells 4 |
| Synonyms | 3110041H08Rik, AW107667, AW546455, LOC102552386, NF-AT3, nuclear factor of activated T-cells 4, nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NFATC4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- regulatory domain
- DNA binding domain
- nucleic acid binding
- IPT
- Rel homology dimerization domain
- transcription activation domain
- transcription factor binding
- calcineurin-binding domain
- protein binding
- sequence-specific DNA binding
- phosphorylation site
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- peroxisome proliferator activated receptor binding
- double-stranded DNA binding
- IPT/TIG domain
- N-terminal sub-domain of the Rel homology domain (RHD)
- transcription factor activity
Pathways
Biological processes and signaling networks where the NFATC4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- anemia
- neoplasia
- early missed abortion
- Waldenström macroglobulinemia
- cutaneous melanoma
- cutaneous melanoma cancer
- Alzheimer disease
- hypoplasia
- growth failure
- preeclampsia
regulated by
- beta-estradiol
- cisplatin
- PD98059
- CSNK1A1
- tetradecanoylphorbol acetate
- methamphetamine
- phenylephrine
- K+
- GSK3
- ionomycin
role in cell
- expression in
- proliferation
- activation in
- binding
- phosphorylation in
- outgrowth
- formation
- formation in
- apoptosis
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cell cortex
- cytosol
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NFATC4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of neuron apoptotic process
- dendrite morphogenesis
- negative regulation of neuron apoptotic process
- negative regulation of transcription from RNA polymerase II promoter
- heart development
- negative regulation of dendrite morphogenesis
- inflammatory response
- patterning of blood vessels
- cellular response to UV
- long-term synaptic potentiation
- positive regulation of tumor necrosis factor production
- negative regulation of synapse maturation
- neuron apoptotic process
- calcineurin-NFAT signaling cascade
- synapse maturation
- cellular respiration
- DNA damage response, signal transduction resulting in induction of apoptosis
- vascular smooth muscle cell development
- regulation of transcription from RNA polymerase II promoter
- long-term memory
- cellular response to lithium ion
- brain-derived neurotrophic factor receptor signaling pathway
- cytokine production
- negative regulation of Wnt receptor signaling pathway
- positive regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- nuclear speck
- cytosol
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- transcription factor binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- peroxisome proliferator activated receptor binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity