Nfatc4 Gene Summary [Mouse]
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including brain-derived neurotrophic factor receptor signaling pathway; long-term memory; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including circulatory system development; intracellular signal transduction; and positive regulation of apoptotic process. Located in cytosol and nucleus. Part of transcription regulator complex. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; heart; and maxillary process. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human NFATC4 (nuclear factor of activated T cells 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nfatc4 |
| Official Name | nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 [Source:MGI Symbol;Acc:MGI:1920431] |
| Ensembl ID | ENSMUSG00000023411 |
| Bio databases IDs | |
| Aliases | nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 |
| Synonyms | 3110041H08Rik, AW107667, AW546455, LOC102552386, NF-AT3, nuclear factor of activated T-cells 4, nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nfatc4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- regulatory domain
- DNA binding domain
- nucleic acid binding
- IPT
- Rel homology dimerization domain
- transcription activation domain
- transcription factor binding
- calcineurin-binding domain
- protein binding
- sequence-specific DNA binding
- phosphorylation site
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- peroxisome proliferator activated receptor binding
- double-stranded DNA binding
- IPT/TIG domain
- N-terminal sub-domain of the Rel homology domain (RHD)
- transcription factor activity
Pathways
Biological processes and signaling networks where the Nfatc4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- April Mediated Signaling
- B Cell Activating Factor Signaling
- Calcium Signaling
- Cellular Effects of Sildenafil (Viagra)
- Chronic Myeloid Leukemia Signaling
- fMLP Signaling in Neutrophils
- G-Protein Coupled Receptor Signaling
- Glucocorticoid Receptor Signaling
- Gαq Signaling
- IL-12 Signaling and Production in Macrophages
- Natural Killer Cell Signaling
- Netrin Signaling
- PI3K Signaling in B Lymphocytes
- PKCθ Signaling in T Lymphocytes
- Protein Kinase A Signaling
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NFAT in Cardiac Hypertrophy
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Systemic Lupus Erythematosus Signaling
- Th1 and Th2 Activation Pathway
- Th1 Pathway
- Th17 Activation Pathway
- Wnt/Ca+ pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- anemia
- neoplasia
- early missed abortion
- Waldenström macroglobulinemia
- cutaneous melanoma
- cutaneous melanoma cancer
- Alzheimer disease
- hypoplasia
- growth failure
- preeclampsia
regulated by
- beta-estradiol
- cisplatin
- PD98059
- CSNK1A1
- tetradecanoylphorbol acetate
- methamphetamine
- phenylephrine
- K+
- GSK3
- ionomycin
role in cell
- expression in
- proliferation
- activation in
- binding
- phosphorylation in
- outgrowth
- formation
- formation in
- apoptosis
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cell cortex
- cytosol
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nfatc4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of neuron apoptotic process
- dendrite morphogenesis
- negative regulation of neuron apoptotic process
- negative regulation of transcription from RNA polymerase II promoter
- heart development
- negative regulation of dendrite morphogenesis
- inflammatory response
- patterning of blood vessels
- cellular response to UV
- long-term synaptic potentiation
- positive regulation of tumor necrosis factor production
- negative regulation of synapse maturation
- neuron apoptotic process
- calcineurin-NFAT signaling cascade
- synapse maturation
- cellular respiration
- DNA damage response, signal transduction resulting in induction of apoptosis
- vascular smooth muscle cell development
- regulation of transcription from RNA polymerase II promoter
- long-term memory
- cellular response to lithium ion
- brain-derived neurotrophic factor receptor signaling pathway
- cytokine production
- negative regulation of Wnt receptor signaling pathway
- positive regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- nuclear speck
- cytosol
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- transcription factor binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- peroxisome proliferator activated receptor binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity