SLA2 Gene Summary [Human]
This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SLA2 |
| Official Name | Src like adaptor 2 [Source:HGNC Symbol;Acc:HGNC:17329] |
| Ensembl ID | ENSG00000101082 |
| Bio databases IDs | |
| Aliases | Src like adaptor 2 |
| Synonyms | A930009E21Rik, C20orf156, LOC102554229, MARS, RGD1562071, SLAP-2, Src-like-adaptor 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLA2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding activity, bridging
- Src homology 2 (SH2) domain
- protein binding
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- diabetic nephropathy
- epithelial basal cell carcinoma
role in cell
- differentiation
- activation
- function
- immune response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- Cytoplasm
- Golgi Apparatus
- granules
- cytosol
- nucleoplasm
- late endosomes
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLA2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- antigen receptor-mediated signaling pathway
- negative regulation of T cell receptor signaling pathway
- negative regulation of calcium-mediated signaling
- T cell activation
- phosphatidylinositol phosphorylation
- B cell mediated immunity
- regulation of immune response
Cellular Component
Where in the cell the gene product is active
- phosphatidylinositol 3-kinase complex
- cytoplasm
- intracellular membrane-bounded organelle
- late endosome
- cytosol
- endosome membrane
- Golgi apparatus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling adaptor activity
- 1-phosphatidylinositol-3-kinase regulator activity