Sla2 Gene Summary [Mouse]
Predicted to enable signaling adaptor activity. Acts upstream of or within T cell activation. Located in late endosome and plasma membrane. Is expressed in thymus primordium. Orthologous to human SLA2 (Src like adaptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sla2 |
| Official Name | Src-like-adaptor 2 [Source:MGI Symbol;Acc:MGI:1925049] |
| Ensembl ID | ENSMUSG00000027636 |
| Bio databases IDs | |
| Aliases | Src-like-adaptor 2 |
| Synonyms | A930009E21Rik, C20orf156, LOC102554229, MARS, RGD1562071, SLAP-2, Src-like-adaptor 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sla2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding activity, bridging
- Src homology 2 (SH2) domain
- protein binding
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- diabetic nephropathy
- epithelial basal cell carcinoma
phenotypes
- abnormal cranium morphology
- abnormal digit morphology
- decreased NK cell number
- enhanced cued conditioning behavior
- increased circulating HDL cholesterol level
role in cell
- differentiation
- activation
- function
- immune response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- Cytoplasm
- Golgi Apparatus
- granules
- cytosol
- nucleoplasm
- late endosomes
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sla2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- antigen receptor-mediated signaling pathway
- negative regulation of T cell receptor signaling pathway
- negative regulation of calcium-mediated signaling
- T cell activation
- phosphatidylinositol phosphorylation
- B cell mediated immunity
- regulation of immune response
Cellular Component
Where in the cell the gene product is active
- phosphatidylinositol 3-kinase complex
- cytoplasm
- intracellular membrane-bounded organelle
- late endosome
- cytosol
- endosome membrane
- Golgi apparatus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling adaptor activity
- 1-phosphatidylinositol-3-kinase regulator activity