RASSF5
RASSF5 Gene Summary
This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | RASSF5 |
| Official Name | Ras association domain family member 5 [Source:HGNC Symbol;Acc:HGNC:17609] |
| Ensembl ID | ENSG00000266094 |
| Bio databases IDs | |
| Aliases | Ras association domain family member 5, novel Ras effector 1, regulator for cell adhesion and polarization enriched in lymphoid tissues |
| Synonyms | 1300019G20Rik,AU042887,MAXP1,NORE1,Nore1A,NORE1B,RAPL,Ras association domain family member 5,Ras association (RalGDS/AF-6) domain family member 5,RASSF3 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- central domain
- coiled-coil domain
- protein binding
- proline rich domain
- identical protein binding
- SARAH_SF
- SARAH domain
- Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
- Ubl1_cv_Nsp3_N-like
- Ras/Rap binding domain
- protein kinase C conserved region 1 (C1 domain) superfamily
- Ras-binding domain
- zinc finger domain
- MST1/2 binding domain
Pathways
Biological processes and signaling networks where the RASSF5 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- RASSF2
- HNF4A
- HRAS
- RASSF1
- STK4
- MDM2
- RAS
- AMOTL2
- TP53
- MRAS
disease
- neoplasia
- lung carcinoma process
- lung cancer
- epithelial cancer
- thoracic cancer
- epithelial neoplasia
- cancer
- hypoplasia
- colorectal cancer
- abdominal cancer
regulated by
- beta-estradiol
- TNF
- KRAS
- RAP
- RASSF5
- TRIM37
- ITCH
- ovalbumin-alum
- decitabine
- 8-bromo-cAMP
regulates
- RELA
- TNFRSF1A
- NFkB (complex)
- IL6
- TNF
- BAX
- ICAM1
- TP53
- EEF2
- CXCL8
role in cell
- apoptosis
- cell death
- growth
- binding in
- expression in
- dephosphorylation in
- phosphorylation in
- proliferation
- activation in
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- perinuclear region
- Nucleus
- vesicles
- centrosome
- Mitochondria
- microtubules
- microtubule organizing centers
- nucleoli
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the RASSF5 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- negative regulation of lymphocyte proliferation
- lymphocyte proliferation
- signal transduction
- apoptotic process
- positive regulation of protein ubiquitination
- regulation of protein localization to nucleus
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- cytoplasm
- microtubule
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- metal ion binding