IGHG2
IGHG2 Gene Summary
Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Predicted to be involved in several processes, including activation of immune response; defense response to other organism; and phagocytosis. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Immunoglobulin Constant Gene |
| Official Symbol | IGHG2 |
| Official Name | immunoglobulin heavy constant gamma 2 (G2m marker) [Source:HGNC Symbol;Acc:HGNC:5526] |
| Ensembl ID | ENSG00000211893 |
| Bio databases IDs | |
| Aliases | immunoglobulin heavy constant gamma 2 (G2m marker) |
| Synonyms | Ig gamma-2 chain c,Ig γ-2 chain c,immunoglobulin heavy constant gamma 2 (G2m marker),immunoglobulin heavy constant γ 2 (G2m marker),LOC100294459 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CH2 domain (from immunoglobulin)
- CH3 domain (from immunoglobulin)
- hinge domain
- heavy chain domain, constant
- protein binding
Pathways
Biological processes and signaling networks where the IGHG2 gene plays a role, providing insight into its function and relevance in health or disease.
- Allograft Rejection Signaling
- Autoimmune Thyroid Disease Signaling
- B Cell Receptor Signaling
- Communication between Innate and Adaptive Immune Cells
- Dendritic Cell Maturation
- FcγRIIB Signaling in B Lymphocytes
- IL-12 Signaling and Production in Macrophages
- IL-15 Signaling
- p70S6K Signaling
- Phagosome Formation
- PI3K Signaling in B Lymphocytes
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NFAT in Regulation of the Immune Response
- Systemic Lupus Erythematosus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- NRSN1
- PRKN
- AKR1A1
- PAN2
- USP36
- PMAIP1
- STK4
- EBF2
- ZRANB1
- TP53
disease
- endometriosis
- diabetic retinopathy
- Marfan syndrome
- complete testicular feminization syndrome
- global developmental delay with intellectual disability
- idiopathic pulmonary fibrosis
regulated by
- IL4
- methylprednisolone
- Bet V1
- SNAI2
- SOX9
- CD40
- IL21
- Bacillus anthracis
regulates
role in cell
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the IGHG2 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- complement activation, classical pathway
- adaptive immune response
- antibacterial humoral response
- B cell receptor signaling pathway
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- blood microparticle
- immunoglobulin complex, circulating
- extracellular region
- plasma membrane
- IgG immunoglobulin complex
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- antigen binding
- immunoglobulin receptor binding