GMEB2 Gene Summary [Human]
This gene is a member of KDWK gene family. The product of this gene associates with GMEB1 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. This gene appears to use multiple polyadenylation sites. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GMEB2 |
| Official Name | glucocorticoid modulatory element binding protein 2 [Source:HGNC Symbol;Acc:HGNC:4371] |
| Ensembl ID | ENSG00000101216 |
| Bio databases IDs | |
| Aliases | glucocorticoid modulatory element binding protein 2 |
| Synonyms | glucocorticoid modulatory element binding protein 2, P79PIF, PIF79 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GMEB2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- protein binding
- sequence-specific DNA binding
- SAND domain
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- prostate cancer
- prostatic carcinoma
- colorectal cancer
- idiopathic pulmonary fibrosis
- hepatoid gastric adenocarcinoma
- gastric epithelial cancer
regulated by
- YTHDF1
- IL12 (family)
regulates
- DNA endogenous promoter
- RNA polymerase II
- NFkB (complex)
- ADRM1
- dexamethasone 21-methanesulfonate
- DNA promoter
role in cell
- proliferation
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GMEB2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity