ADRM1 Gene Summary [Human]
This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Details
| Type | Protein Coding |
| Official Symbol | ADRM1 |
| Official Name | adhesion regulating molecule 1 [Source:HGNC Symbol;Acc:HGNC:15759] |
| Ensembl ID | ENSG00000130706 |
| Bio databases IDs | |
| Aliases | adhesion regulating molecule 1, ADRM1 26S proteasome ubiquitin receptor |
| Synonyms | 1110063P18Rik, 2510006J17Rik, adhesion regulating molecule 1 26S proteasome ubiquitin receptor, ADRM1 26S proteasome ubiquitin receptor, ARM-1, GP110, NAP110, PSMD16, Rpn13 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ADRM1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Proteasome complex subunit Rpn13 ubiquitin receptor
- binding protein
- protease binding
- UCH-binding domain
- protein binding
- enzyme regulator activity
- Pleckstrin homology-like domain
- protease activator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
role in cell
- differentiation
- expression in
- cell viability
- binding in
- activation in
- proliferation
- development
- degradation in
- inactivation in
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- Cytoplasm
- Nucleus
- cytoplasmic particles
- cytosol
- nucleoplasm
- synaptosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ADRM1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- proteasome assembly
- transcription elongation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- cytosol
- proteasome complex
- proteasome regulatory particle, lid subcomplex
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- endopeptidase activator activity
- protein binding
- proteasome binding
- protease binding