BPI Gene Summary [Human]
This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms. [provided by RefSeq, Nov 2014]
Details
| Type | Protein Coding |
| Official Symbol | BPI |
| Official Name | bactericidal permeability increasing protein [Source:HGNC Symbol;Acc:HGNC:1095] |
| Ensembl ID | ENSG00000101425 |
| Bio databases IDs | |
| Aliases | bactericidal permeability increasing protein, BPI fold containing family D, member 1 |
| Synonyms | 9230105K17, 9230105K17Rik, bactericidal permeability increasing protein, bactericidal/permeability-increasing protein, bactericidal permeablility increasing protein, BPIFD1, CAP57, LOC100292257, rBPI |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BPI often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid binding
- BPI
- lipopolysaccharide binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- sepsis
- diabetic nephropathy
- severe acute respiratory syndrome
- Crohn disease
- tuberculosis
- colitis
role in cell
- proliferation
- activation
- growth
- apoptosis
- number
- killing
- lysis
- function
- activation in
- growth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- secretory granule lumen
- azurophil granule lumen
- Cytoplasm
- cell surface
- Extracellular Space
- membrane surface
- cellular membrane
- Endoplasmic Reticulum
- granules
- azurophil granules
- specific granules
- stress granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BPI gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of interleukin-6 production
- negative regulation of macrophage activation
- defense response to Gram-negative bacterium
- negative regulation of interleukin-8 production
- innate immune response
- lipopolysaccharide-mediated signaling pathway
- negative regulation of tumor necrosis factor production
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- specific granule lumen
- membrane
- extracellular region
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- lipopolysaccharide binding