IKBKB
IKBKB Gene Summary
The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]
Details
| Type | Protein Coding |
| Official Symbol | IKBKB |
| Official Name | inhibitor of nuclear factor kappa B kinase subunit beta [Source:HGNC Symbol;Acc:HGNC:5960] |
| Ensembl ID | ENSG00000104365 |
| Bio databases IDs | |
| Aliases | inhibitor of nuclear factor kappa B kinase subunit beta |
| Synonyms | AIM-1,I kappa b beta,Ikb Kinase Beta,Ikb Kinase β,IKK-2,IKKB,IKK[b],IKK-beta,IKK-β,IMD15,IMD15A,IMD15B,inhibitor of kappaB kinase beta,inhibitor of kappaB kinase β,inhibitor of nuclear factor kappa B kinase subunit beta,inhibitor of nuclear factor κ B kinase subunit β,i κ b kinase,I κ b β,NFKBIKB |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- I-kappa-kinase-beta NEMO binding domain
- protein serine/threonine kinase
- protein kinase
- IQBAL scaffold dimerization domain
- ATP-binding domain
- ATP binding
- leucine zipper domain
- ubiquitin-like domain
- Protein kinase domain
- identical protein binding
- activation loop
- Ubiquitin family
- serine-rich region
- Ubiquitin homologues
- ETGE motif
- helix-loop-helix domain
- Tyrosine kinase, catalytic domain
- scaffold dimerization domain
- Protein kinase (unclassified specificity)
- protein kinase binding
- Protein tyrosine and serine/threonine kinase
- protein phosphatase binding
- protein binding
- receptor binding
- phosphorylation site
- kinase
- Serine/Threonine protein kinases, catalytic domain
- NEMO-binding domain
- Translocation domain
- kinase domain
- binding protein
- Protein Kinases, catalytic domain
- ubiquitin-like domain-like domain
- Ubl1_cv_Nsp3_N-like
- protein homodimerization
- ikappaB kinase
- protein heterodimerization
Pathways
Biological processes and signaling networks where the IKBKB gene plays a role, providing insight into its function and relevance in health or disease.
- Angiopoietin Signaling
- Antioxidant Action of Vitamin C
- April Mediated Signaling
- B Cell Activating Factor Signaling
- CD27 Signaling in Lymphocytes
- CD40 Signaling
- Glucocorticoid Receptor Signaling
- HER-2 Signaling in Breast Cancer
- IL-17A Signaling in Airway Cells
- IL-6 Signaling
- Induction of Apoptosis by HIV1
- LPS-stimulated MAPK Signaling
- Lymphotoxin β Receptor Signaling
- Myc Mediated Apoptosis Signaling
- NF-κB Activation by Viruses
- NF-κB Signaling
- PEDF Signaling
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of RIG1-like Receptors in Antiviral Innate Immunity
- Small Cell Lung Cancer Signaling
- TNFR1 Signaling
- TNFR2 Signaling
- Toll-like Receptor Signaling
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- HSP90 (family)
- DBN1
- CHUK
- GTF2E1
- CREBBP
- COPS5
- MUC1
- MAP3K1
- EGR1
- TSC1
disease
- edema
- bleeding
- neoplasia
- cancer
- epithelial neoplasia
- epithelial cancer
- abdominal cancer
- breast cancer
- digestive system cancer
- fibrosis
regulated by
- LTF
- TNF
- CD44
- TGFB1
- rosiglitazone
- YC-1
- natural killer cells
- KLHL21
- NR3C1
- MAP3K7
regulates
- IL5
- MMP9
- ICAM1
- CDH1
- MMP2
- RELA
- NFKBIA
- VEGF
- DLG4
- GLI1
role in cell
- proliferation
- production in
- binding
- growth
- expression in
- invasion by
- aggregation
- phosphorylation in
- cell death
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- cytoplasmic fiber
- intracellular space
- Nucleus
- Mitochondria
- immunological synapses
- cytosol
- cytoplasmic face of plasma membrane
- membrane rafts
- plasma
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the IKBKB gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- Fc-epsilon receptor signaling pathway
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- response to virus
- positive regulation of transcription from RNA polymerase II promoter
- protein phosphorylation
- positive regulation of NF-kappaB transcription factor activity
- stimulatory C-type lectin receptor signaling pathway
- cortical actin cytoskeleton organization
- inflammatory response
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
- MyD88-dependent toll-like receptor signaling pathway
- positive regulation of transcription, DNA-dependent
- protein maturation
- cellular response to tumor necrosis factor
- T cell receptor signaling pathway
- stress-activated MAPK cascade
- I-kappaB kinase/NF-kappaB cascade
- regulation of phosphorylation
- tumor necrosis factor-mediated signaling pathway
- innate immune response
- negative regulation of myosin-light-chain-phosphatase activity
- regulation of tumor necrosis factor-mediated signaling pathway
- toll-like receptor 3 signaling pathway
- interleukin-1-mediated signaling pathway
- peptidyl-serine phosphorylation
- TRIF-dependent toll-like receptor signaling pathway
- protein localization in plasma membrane
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- cytoplasm
- IkappaB kinase complex
- membrane raft
- cytosol
- CD40 receptor complex
- internal side of plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- scaffold protein binding
- ATP binding
- protein kinase binding
- identical protein binding
- protein binding
- protein homodimerization activity
- protein heterodimerization activity
- IkappaB kinase activity
- protein kinase activity
- protein serine/threonine kinase activity