PGF Gene Summary [Human]
Enables growth factor activity. Involved in positive regulation of cell population proliferation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in several diseases, including brain ischemia; diabetic neuropathy; glioblastoma; myocardial infarction; and pancreatic endocrine carcinoma. Biomarker of several diseases, including artery disease (multiple); autoimmune disease of musculoskeletal system (multiple); epilepsy (multiple); limited scleroderma; and pancreatic endocrine carcinoma. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PGF |
| Official Name | placental growth factor [Source:HGNC Symbol;Acc:HGNC:8893] |
| Ensembl ID | ENSG00000119630 |
| Bio databases IDs | |
| Aliases | placental growth factor, placenta growth factor |
| Synonyms | D12S1900, Pgf2, PGFL, PIGF, PIGF1, placental growth factor, PLGF, SHGC-10760, VRP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PGF often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- PDGF
- protein binding
- vascular endothelial growth factor receptor binding
- identical protein binding
- growth factor
Pathways
Biological processes and signaling networks where the PGF gene in human plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Bladder Cancer Signaling
- Clathrin-mediated Endocytosis Signaling
- Colorectal Cancer Metastasis Signaling
- Endocannabinoid Cancer Inhibition Pathway
- eNOS Signaling
- Estrogen Receptor Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HIF1α Signaling
- IL-17 Signaling
- IL-8 Signaling
- ILK Signaling
- mTOR Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- Osteoarthritis Pathway
- Ovarian Cancer Signaling
- Pancreatic Adenocarcinoma Signaling
- Role of JAK family kinases in IL-6-type Cytokine Signaling
- Role of JAK2 in Hormone-like Cytokine Signaling
- TR/RXR Activation
- VEGF Family Ligand-Receptor Interactions
- VEGF Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- epithelial cancer
- epithelial neoplasia
- rheumatoid arthritis
- neoplasia
- metastatic colon cancer
- microsatellite instability high colon cancer
- advanced colon cancer
- advanced rectal cancer
- metastatic rectal cancer
role in cell
- expression in
- proliferation
- cell death
- apoptosis
- activation in
- invasion by
- binding in
- phosphorylation in
- recruitment in
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- Plasma Membrane
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PGF gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive chemotaxis
- signal transduction
- positive regulation of cell proliferation
- sprouting angiogenesis
- cell-cell signaling
- vascular endothelial growth factor signaling pathway
- positive regulation of angiogenesis
- positive regulation of mast cell chemotaxis
- vascular endothelial growth factor receptor signaling pathway
- response to hypoxia
- positive regulation of cell division
- positive regulation of protein phosphorylation
- cell differentiation
- positive regulation of endothelial cell proliferation
- induction of positive chemotaxis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- membrane
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- vascular endothelial growth factor receptor binding
- chemoattractant activity
- heparin binding