TMED9 Gene Summary [Human]
This gene is a member of a family of genes encoding transport proteins located in the endoplasmic reticulum and the Golgi. A similar gene in mouse is the target of microRNA miR-296, which is part of an imprinted cluster. [provided by RefSeq, Jul 2016]
Details
| Type | Protein Coding |
| Official Symbol | TMED9 |
| Official Name | transmembrane p24 trafficking protein 9 [Source:HGNC Symbol;Acc:HGNC:24878] |
| Ensembl ID | ENSG00000184840 |
| Bio databases IDs | |
| Aliases | transmembrane p24 trafficking protein 9 |
| Synonyms | 2400003B06Rik, GMP25, GP25L2, HSGP25L2G, p24a2, p24 alpha2, p25, RGD1307627, transmembrane p24 trafficking protein 9 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TMED9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytoplasmic domain
- protein binding
- cytosolic tail domain
- emp24/gp25L/p24 family/GOLD
- transporter
- syntaxin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi-enriched fraction
- membrane fraction
- pH resistant lipid raft fraction
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- ER-to-Golgi intermediate compartment
- endoplasmic reticulum membrane
- Golgi membrane
- nuclear envelope
- synaptic vesicles
- transport vesicles
- smooth endoplasmatic reticulum
- rough endoplasmatic reticulum
- cis Golgi cisternae
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TMED9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- protein exit from endoplasmic reticulum
- Golgi organization
- positive regulation of organelle organization
- COPI coating of Golgi vesicle
- early endosome to Golgi transport
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extracellular vesicular exosome
- synaptic vesicle
- trans-Golgi network transport vesicle
- ER to Golgi transport vesicle
- Golgi apparatus
- endoplasmic reticulum
- Golgi membrane
- endoplasmic reticulum-Golgi intermediate compartment
- transport vesicle
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- syntaxin binding
- cargo receptor activity