CORO2B Gene Summary [Human]
Enables talin binding activity and vinculin binding activity. Acts upstream of or within several processes, including negative regulation of cell-substrate adhesion; regulation of actin cytoskeleton organization; and regulation of establishment of protein localization. Located in focal adhesion. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CORO2B |
| Official Name | coronin 2B [Source:HGNC Symbol;Acc:HGNC:2256] |
| Ensembl ID | ENSG00000103647 |
| Bio databases IDs | |
| Aliases | coronin 2B, clipin C, coronin, actin-binding, 2B |
| Synonyms | CLIPINC, COR5, coronin 2B, coronin, actin binding protein, 2B, E130012P22RIK |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CORO2B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Type of WD40 repeat
- WD40 repeats
- cytoskeletal protein binding
- WD domain, G-beta repeat
- WD40
- vinculin binding
- protein binding
- Domain of unknown function (DUF1899)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- seizures
- conotruncal heart malformations
- prostate cancer
- severe acute respiratory syndrome
- Huntington disease
role in cell
- activity
- stalling
- organization
- assembly
- complexity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- focal adhesions
- actin stress fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CORO2B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of stress fiber assembly
- regulation of actin cytoskeleton organization
- regulation of glomerular filtration
- negative regulation of cell-substrate adhesion
- regulation of cellular response to stress
- focal adhesion assembly
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- cytoplasm
- membrane
- actin cytoskeleton
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- actin binding
- vinculin binding