SFRP1 Gene Summary [Human]
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]
Details
| Type | Protein Coding |
| Official Symbol | SFRP1 |
| Official Name | secreted frizzled related protein 1 [Source:HGNC Symbol;Acc:HGNC:10776] |
| Ensembl ID | ENSG00000104332 |
| Bio databases IDs | |
| Aliases | secreted frizzled related protein 1 |
| Synonyms | 2210415K03RIK, FRP, FRP-1, FrzA, SARP2, Secreted frizzled-related 1, secreted frizzled-related protein 1, SECRETED FRIZZLE-RELATED SEQUENCE, Sfrp |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SFRP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NTR_like
- lysine rich domain
- Wnt-protein binding
- cysteine endopeptidase
- frizzled binding
- Fz domain
- protein binding
- heparin binding
- identical protein binding
- transmembrane receptor
- cysteine rich domain
- CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
Pathways
Biological processes and signaling networks where the SFRP1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- edema
- breast cancer
- diabetic nephropathy
- syndactyly
- endometriosis
- rectum cancer
- hepatocellular carcinoma
- oral squamous cell carcinoma
- squamous-cell carcinoma
- renal clear cell adenocarcinoma
role in cell
- expression in
- proliferation
- activation
- cell death
- formation
- phosphorylation in
- apoptosis
- growth
- transcription in
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Extracellular Space
- cytosol
- neurites
- extracellular matrix
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SFRP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- male gonad development
- planar cell polarity pathway involved in neural tube closure
- negative regulation of planar cell polarity pathway involved in axis elongation
- regulation of angiogenesis
- positive regulation of fat cell differentiation
- negative regulation of bone remodeling
- prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
- dorsal/ventral axis specification
- female gonad development
- cellular response to prostaglandin E stimulus
- regulation of branching involved in prostate gland morphogenesis
- positive regulation of GTPase activity
- hemopoietic progenitor cell differentiation
- negative regulation of androgen receptor signaling pathway
- planar cell polarity pathway involved in axis elongation
- positive regulation of cell growth
- negative regulation of transcription, DNA-dependent
- cellular response to BMP stimulus
- negative regulation of cell growth
- positive regulation of transcription, DNA-dependent
- BMP signaling pathway
- regulation of neuron projection development
- cellular response to hypoxia
- positive regulation of epithelial cell proliferation
- neural crest cell fate commitment
- positive regulation of non-canonical Wnt receptor signaling pathway
- positive regulation of canonical Wnt receptor signaling pathway
- negative regulation of B cell differentiation
- response to organic cyclic compound
- cellular response to transforming growth factor beta stimulus
- negative regulation of gene expression
- cellular response to X-ray
- positive regulation of focal adhesion assembly
- positive regulation of stress fiber assembly
- positive regulation of cell-matrix adhesion
- cellular response to growth factor stimulus
- negative regulation of epithelial cell proliferation
- negative regulation of Wnt receptor signaling pathway
- positive regulation of Wnt receptor signaling pathway
- negative regulation of cell migration
- negative regulation of osteoblast proliferation
- negative regulation of cell proliferation
- positive regulation of cell proliferation
- extrinsic apoptotic signaling pathway
- negative regulation of insulin secretion
- response to xenobiotic stimulus
- bone trabecula formation
- negative regulation of osteoblast differentiation
- cellular response to estradiol stimulus
- negative regulation of epithelial to mesenchymal transition
- negative regulation of fibroblast proliferation
- negative regulation of osteoclast differentiation
- osteoblast differentiation
- somatic stem cell maintenance
- canonical Wnt receptor signaling pathway
- cellular response to tumor necrosis factor
- negative regulation of peptidyl-tyrosine phosphorylation
- negative regulation of fibroblast apoptotic process
- convergent extension involved in somitogenesis
- positive regulation of fibroblast apoptotic process
- Wnt receptor signaling pathway involved in somitogenesis
- cellular response to fibroblast growth factor stimulus
- hemopoietic stem cell differentiation
- digestive tract morphogenesis
- cellular response to starvation
- stromal-epithelial cell signaling involved in prostate gland development
- cellular response to estrogen stimulus
- negative regulation of canonical Wnt receptor signaling pathway
- osteoclast differentiation
- negative regulation of BMP signaling pathway
- dopaminergic neuron differentiation
- ureteric bud development
- negative regulation of apoptotic process
- positive regulation of apoptotic process
- positive regulation of smoothened signaling pathway
- cellular response to interleukin-1
- negative regulation of ossification
- cellular response to vitamin D
- non-canonical Wnt receptor signaling pathway
- regulation of cell cycle process
- cellular response to heparin
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- cytosol
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- frizzled binding
- identical protein binding
- protein binding
- cysteine-type endopeptidase activity
- heparin binding
- Wnt-protein binding