WNT2 Gene Summary [Human]
This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | WNT2 |
| Official Name | Wnt family member 2 [Source:HGNC Symbol;Acc:HGNC:12780] |
| Ensembl ID | ENSG00000105989 |
| Bio databases IDs | |
| Aliases | Wnt family member 2, secreted growth factor |
| Synonyms | 2610510E18Rik, INT1L1, IRP, Mirp, wingless-type MMTV integration site family, member 2, Wnt, Wnt2a, Wnt family member 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human WNT2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wnt
- frizzled binding
- wnt family
- receptor agonist activity
- protein binding
- cytokine
- found in Wnt-1
Pathways
Biological processes and signaling networks where the WNT2 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Axonal Guidance Signaling
- Basal Cell Carcinoma Signaling
- Chronic Myeloid Leukemia Signaling
- Colorectal Cancer Metastasis Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Glioblastoma Multiforme Signaling
- Human Embryonic Stem Cell Pluripotency
- Molecular Mechanisms of Cancer
- Ovarian Cancer Signaling
- PCP pathway
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Transcriptional Regulatory Network in Embryonic Stem Cells
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- uterine serous papillary cancer
- colorectal cancer
- organismal death
- colorectal carcinomagenesis
- Dupuytren contracture
- non-small cell lung cancer
- uterine leiomyoma
- leiomyomatosis
- nonalcoholic fatty liver disease
- lung adenocarcinoma formation
role in cell
- aggregation
- apoptosis
- morphology
- proliferation
- accumulation in
- development
- size
- accumulation
- transformation
- proliferation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human WNT2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cardiac muscle cell proliferation
- positive regulation of cell proliferation
- neurogenesis
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of transcription from RNA polymerase II promoter
- lens development in camera-type eye
- positive regulation of epithelial cell proliferation involved in lung morphogenesis
- epithelial cell proliferation involved in lung morphogenesis
- positive regulation of fibroblast proliferation
- mammary gland epithelium development
- canonical Wnt receptor signaling pathway
- cell proliferation in midbrain
- atrial cardiac muscle tissue morphogenesis
- lung induction
- neuron differentiation
- cell-cell signaling
- cardiac epithelial to mesenchymal transition
- positive regulation of mesenchymal cell proliferation
- cardiac muscle cell proliferation
- cellular response to transforming growth factor beta stimulus
- labyrinthine layer blood vessel development
- cellular response to retinoic acid
- cell fate commitment
- iris morphogenesis
- positive regulation of neurogenesis
- mesenchymal cell proliferation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- frizzled binding
- protein binding
- receptor agonist activity
- cytokine activity