LARP1 Gene Summary [Human]
Enables eukaryotic initiation factor 4E binding activity; nucleic acid binding activity; and ribosomal small subunit binding activity. Involved in several processes, including TORC1 signaling; cellular response to rapamycin; and posttranscriptional regulation of gene expression. Located in cytoplasmic stress granule. Colocalizes with TORC1 complex and polysomal ribosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | LARP1 |
| Official Name | La ribonucleoprotein 1, translational regulator [Source:HGNC Symbol;Acc:HGNC:29531] |
| Ensembl ID | ENSG00000155506 |
| Bio databases IDs | |
| Aliases | La ribonucleoprotein 1, translational regulator |
| Synonyms | 1810024J12Rik, 3110040D16Rik, Lar1, La ribonucleoprotein 1, translational regulator, LARP, Lhp1, mKIAA0731, RGD1306683 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LARP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- La domain
- RNA 7-methylguanosine cap binding
- mRNA 3' UTR binding
- RNA cap binding
- mRNA 5' UTR binding
- DM15
- translation activator
- protein binding
- eukaryotic initiation factor 4E binding
- translation regulator
- ribosomal small subunit binding
- LA motif RNA-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver cancer
- cervical squamous cell carcinoma
- squamous cell cervical cancer
- organismal death
- hepatoblastoma
- cholelithiasis
role in cell
- proliferation
- synthesis in
- growth
- apoptosis
- binding in
- invasion
- replication in
- fitness
- translation in
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- stress granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LARP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- posttranscriptional regulation of gene expression
- positive regulation of translational initiation
- cell proliferation
- positive regulation of macroautophagy
- negative regulation of translational initiation
- positive regulation of translation
- mRNA stabilization
- TOR signaling cascade
- positive regulation of viral genome replication
- translational initiation
- negative regulation of translation
Cellular Component
Where in the cell the gene product is active
- cytoplasmic stress granule
- cytoplasm
- membrane
- cytosol
- TORC1 complex
Molecular Function
What the gene product does at the molecular level
- RNA 7-methylguanosine cap binding
- protein binding
- RNA binding
- mRNA 5'-UTR binding
- translation activator activity
- cadherin binding
- RNA cap binding
- ribosomal small subunit binding
- translation initiation factor binding
- eukaryotic initiation factor 4E binding
- mRNA 3'-UTR binding