Tle5 Gene Summary [Mouse]
This gene encodes a protein that belongs to the Aes (amino-terminal enhancer of split) subgroup of the Groucho/transducin-like Enhancer of split (TLE) family of proteins that function as transcriptional corepressors. The encoded protein plays a role in neurological development and cell-fate determination. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2013]
Details
| Type | Retained Intron |
| Official Symbol | Tle5 |
| Official Name | TLE family member 5, transcriptional modulator [Source:MGI Symbol;Acc:MGI:95806] |
| Ensembl ID | ENSMUSG00000054452 |
| Bio databases IDs | |
| Aliases | TLE family member 5, transcriptional modulator |
| Synonyms | AES, AES-1, ESP1, GAM, GRG, GRG5, TLE family member 5, transcriptional modulator |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tle5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-repressor
- Groucho/TLE N-terminal Q-rich domain
- protein binding
- glutamine-rich domain
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic scoliosis
- growth failure
- systemic autoimmune syndrome
- infection by HIV-1
role in cell
- proliferation
- apoptosis
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tle5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of canonical Wnt receptor signaling pathway
- negative regulation of gene expression
- negative regulation of response to cytokine stimulus
- skeletal system development
- negative regulation of transcription, DNA-dependent
- response to interleukin-1
- Wnt receptor signaling pathway
- positive regulation of anoikis
- negative regulation of protein binding
- regulation of growth
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription corepressor activity