CLIP3 Gene Summary [Human]
This gene encodes a member of the cytoplasmic linker protein 170 family. Members of this protein family contain a cytoskeleton-associated protein glycine-rich domain and mediate the interaction of microtubules with cellular organelles. The encoded protein plays a role in T cell apoptosis by facilitating the association of tubulin and the lipid raft ganglioside GD3. The encoded protein also functions as a scaffold protein mediating membrane localization of phosphorylated protein kinase B. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
Details
| Type | Protein Coding |
| Official Symbol | CLIP3 |
| Official Name | CAP-Gly domain containing linker protein 3 [Source:HGNC Symbol;Acc:HGNC:24314] |
| Ensembl ID | ENSG00000105270 |
| Bio databases IDs | |
| Aliases | CAP-Gly domain containing linker protein 3, CLIP-170-related, restin-like 1 |
| Synonyms | 1500005P14Rik, AI844915, CAP-GLY domain containing linker protein 3, CLIPR-59, LOC108348122, RGD1306245, RSNL1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CLIP3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- microtubule binding domain
- Ankyrin repeats (many copies)
- sphingolipid binding
- lipid binding
- binding protein
- Ankyrin repeats (3 copies)
- CAP-Gly domain
- protein binding
- zDHHC ankyrin repeat binding domain
- CAP_GLY
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- colon adenocarcinoma
- colon epithelial cancer
- cyanosis
- urothelial bladder carcinoma
- transitional cell bladder cancer
- prostate cancer
- endometrial adenocarcinoma
- endometrial adenocarcinoma formation
- prostatic adenocarcinoma
regulates
- D-glucose
- AKT
- ganglioside GD3
- beta tubulin
role in cell
- apoptosis
- binding in
- quantity
- localization
- polymerization
- endocytosis by
- organization
- abnormal morphology
- biogenesis
- regrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble membrane fraction
- raft fractions
- membrane fraction
- cell surface
- Golgi Apparatus
- cytosol
- Golgi stacks
- trans Golgi network
- endosomal membrane
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CLIP3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of glucose transport
- positive regulation of endocytosis
- positive regulation of apoptotic process
- positive regulation of protein phosphorylation
- peptidyl-L-cysteine S-palmitoylation
- cytoplasmic microtubule organization
- fat cell differentiation
- membrane biogenesis
- negative regulation of microtubule polymerization
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- nucleus
- trans-Golgi network
- microtubule plus end
- cell cortex
- membrane raft
- cytosol
- recycling endosome membrane
- Golgi stack
- plasma membrane
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- ganglioside binding
- protein binding
- microtubule plus-end binding
- microtubule binding