HNRNPUL1 Gene Summary [Human]
This gene encodes a nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. This protein binds specifically to adenovirus early-1B-55kDa oncoprotein. It may play an important role in nucleocytoplasmic RNA transport, and its function is modulated by early-1B-55kDa in adenovirus-infected cells. [provided by RefSeq, Mar 2016]
Details
| Type | Protein Coding |
| Official Symbol | HNRNPUL1 |
| Official Name | heterogeneous nuclear ribonucleoprotein U like 1 [Source:HGNC Symbol;Acc:HGNC:17011] |
| Ensembl ID | ENSG00000105323 |
| Bio databases IDs | |
| Aliases | heterogeneous nuclear ribonucleoprotein U like 1, E1B 55kDa associated protein 5 |
| Synonyms | E130317O14Rik, E1B-55kDa-associated, E1B-55KDA-ASSOCIATED protein 5, E1B-AP5, heterogeneous nuclear ribonucleoprotein U-like 1, HNRL1, Hnrnpul, HNRPUL1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HNRNPUL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SAP motif
- SPRY domain
- SAP domain
- enzyme binding
- protein binding
- AAA domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- breast cancer
- aortic valve calcification
role in cell
- expression in
- survival
- repression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- interchromatin granule clusters
- synapse
- paraspeckle-like structures
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HNRNPUL1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- alternative nuclear mRNA splicing, via spliceosome
- RNA processing
- response to virus
Cellular Component
Where in the cell the gene product is active
- nucleus
- synapse
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- enzyme binding