Mast1 Gene Summary [Mouse]
Enables microtubule binding activity. Involved in brain development and cytoskeleton organization. Located in membrane; neuron projection; and neuronal cell body. Is expressed in nervous system; neural retina; and skeletal muscle. Used to study mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations. Human ortholog(s) of this gene implicated in female breast cancer and mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations. Orthologous to human MAST1 (microtubule associated serine/threonine kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mast1 |
| Official Name | microtubule associated serine/threonine kinase 1 [Source:MGI Symbol;Acc:MGI:1861901] |
| Ensembl ID | ENSMUSG00000053693 |
| Bio databases IDs | |
| Aliases | microtubule associated serine/threonine kinase 1 |
| Synonyms | 9430008B02Rik, KIAA0973, MCCCHCM, microtubule associated serine/threonine kinase 1, SAST, SAST170 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mast1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- ATP binding
- canonical PDZ domain
- protein binding
- magnesium ion binding
- Protein kinase domain
- PDZ domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- microtubule binding
- Protein Kinases, catalytic domain
- Domain of unknown function (DUF1908)
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations
- metabolic syndrome X
- urothelial bladder carcinoma
- transitional cell bladder cancer
- endometrial adenocarcinoma
- endometrial adenocarcinoma formation
- lung adenocarcinoma
- lung adenocarcinoma formation
- lung squamous cell carcinoma
role in cell
- phosphorylation in
- cisplatin resistance
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- postsynaptic density (PSD) fractions
- cellular membrane
- Nucleus
- Plasma Membrane
- acrosome
- neurites
- microsomal membrane
- membrane processes
- perikaryon
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mast1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoskeleton organization
- brain development
- protein phosphorylation
- peptidyl-serine phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- dendrite
- cytoskeleton
- cytoplasm
- neuronal cell body
- neuron projection
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- protein binding
- protein serine/threonine kinase activity
- microtubule binding