HBP1 Gene Summary [Human]
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of lipid transport; negative regulation of reactive oxygen species biosynthetic process; and negative regulation of transcription by RNA polymerase II. Located in nuclear speck. Biomarker of osteoarthritis. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | HBP1 |
| Official Name | HMG-box transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:23200] |
| Ensembl ID | ENSG00000105856 |
| Bio databases IDs | |
| Aliases | HMG-box transcription factor 1 |
| Synonyms | 1700058O05Rik, C330012F01Rik, high mobility group box transcription factor 1, Hmgb1, HMG-box transcription factor 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HBP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- A-box
- transcription regulator
- nucleic acid binding
- MAPK binding site
- high mobility group (HMG)-box domain superfamily
- protein binding
- sequence-specific DNA binding
- retinoblastoma protein binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- transcription repression domain
- double-stranded DNA binding
- HMG (high mobility group) box
- HMG-box domain
- Ataxin-1 and HBP1 module (AXH)
- high mobility group
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- Alzheimer disease
- invasive breast cancer
- COVID-19
- pilocarpine-induced status epilepticus
- Huntington disease
- chromosomal instability
role in cell
- expression in
- growth
- activation in
- phosphorylation in
- proliferation
- migration
- transcription in
- signaling in
- activation
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HBP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Wnt receptor signaling pathway
- regulation of cell cycle
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity