CPEB3 Gene Summary [Human]
Enables mRNA 3'-UTR binding activity and translation factor activity, RNA binding. Involved in cellular response to amino acid stimulus; negative regulation of transcription by RNA polymerase II; and positive regulation of mRNA catabolic process. Located in several cellular components, including cytosol; midbody; and nucleoplasm. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CPEB3 |
| Official Name | cytoplasmic polyadenylation element binding protein 3 [Source:HGNC Symbol;Acc:HGNC:21746] |
| Ensembl ID | ENSG00000107864 |
| Bio databases IDs | |
| Aliases | cytoplasmic polyadenylation element binding protein 3 |
| Synonyms | 4831444O18Rik, AC113124.1, CPE-BP3, cytoplasmic polyadenylation element binding protein 3, mKIAA0940, RGD1564670 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CPEB3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleic acid binding translation factor
- RNA recognition motif (RRM) superfamily
- Cytoplasmic polyadenylation element-binding protein ZZ domain
- mRNA 3' UTR binding
- RNA recognition motif
- nucleic acid binding translation repressor
- protein binding
- translation regulator
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- multiple sclerosis
- non-insulin-dependent diabetes mellitus
- hepatitis B virus-related hepatocellular carcinoma
- liver cancer
- epithelial cancer
- hepatocellular carcinoma
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- breast carcinoma
role in cell
- expression in
- function
- quantity
- cell death
- abnormal morphology
- development
- translation in
- long term synaptic depression
- plasticity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- postsynaptic region
- Nucleus
- Plasma Membrane
- midbody
- cytosol
- nucleoplasm
- neurites
- synapse
- dendrites
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CPEB3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- 3'-UTR-mediated mRNA destabilization
- positive regulation of translation
- positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- regulation of dendritic spine development
- positive regulation of dendritic spine development
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
- negative regulation of cytoplasmic translational elongation
- translation
- long-term memory
- negative regulation of transcription from RNA polymerase II promoter
- cellular response to amino acid stimulus
- regulation of synaptic plasticity
- negative regulation of cytoplasmic translation
- negative regulation of translation
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- dendrite
- nucleus
- cytoplasm
- cytosol
- synapse
- midbody
- CCR4-NOT complex
- neuron projection
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- mRNA 3'-UTR AU-rich region binding
- ribosome binding
- translation repressor activity, nucleic acid binding
- RNA stem-loop binding
- translation factor activity, nucleic acid binding
- mRNA 3'-UTR binding