Cpeb3 Gene Summary [Mouse]
Enables RNA binding activity; mRNA regulatory element binding translation repressor activity; and translation factor activity, RNA binding. Involved in several processes, including long-term memory; positive regulation of long-term synaptic potentiation; and regulation of translation. Located in several cellular components, including apical dendrite; nucleus; and synapse. Is active in glutamatergic synapse. Is expressed in several structures, including early conceptus; metanephros; neocortex; and oocyte. Orthologous to human CPEB3 (cytoplasmic polyadenylation element binding protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cpeb3 |
| Official Name | cytoplasmic polyadenylation element binding protein 3 [Source:MGI Symbol;Acc:MGI:2443075] |
| Ensembl ID | ENSMUSG00000039652 |
| Bio databases IDs | |
| Aliases | cytoplasmic polyadenylation element binding protein 3 |
| Synonyms | 4831444O18Rik, AC113124.1, CPE-BP3, cytoplasmic polyadenylation element binding protein 3, mKIAA0940, RGD1564670 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cpeb3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleic acid binding translation factor
- RNA recognition motif (RRM) superfamily
- Cytoplasmic polyadenylation element-binding protein ZZ domain
- mRNA 3' UTR binding
- RNA recognition motif
- nucleic acid binding translation repressor
- protein binding
- translation regulator
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- multiple sclerosis
- non-insulin-dependent diabetes mellitus
- hepatitis B virus-related hepatocellular carcinoma
- liver cancer
- epithelial cancer
- hepatocellular carcinoma
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- breast carcinoma
role in cell
- expression in
- function
- quantity
- cell death
- abnormal morphology
- development
- translation in
- long term synaptic depression
- plasticity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- postsynaptic region
- Nucleus
- Plasma Membrane
- midbody
- cytosol
- nucleoplasm
- neurites
- synapse
- dendrites
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cpeb3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- 3'-UTR-mediated mRNA destabilization
- positive regulation of translation
- positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- regulation of dendritic spine development
- positive regulation of dendritic spine development
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
- negative regulation of cytoplasmic translational elongation
- translation
- long-term memory
- negative regulation of transcription from RNA polymerase II promoter
- cellular response to amino acid stimulus
- regulation of synaptic plasticity
- negative regulation of cytoplasmic translation
- negative regulation of translation
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- dendrite
- nucleus
- cytoplasm
- cytosol
- synapse
- midbody
- CCR4-NOT complex
- neuron projection
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- mRNA 3'-UTR AU-rich region binding
- ribosome binding
- translation repressor activity, nucleic acid binding
- RNA stem-loop binding
- translation factor activity, nucleic acid binding
- mRNA 3'-UTR binding