AKAP10 Gene Summary [Human]
This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. Polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2012]
Details
| Type | Protein Coding |
| Official Symbol | AKAP10 |
| Official Name | A-kinase anchoring protein 10 [Source:HGNC Symbol;Acc:HGNC:368] |
| Ensembl ID | ENSG00000108599 |
| Bio databases IDs | |
| Aliases | A-kinase anchoring protein 10, dual-specificity A-kinase anchoring protein 2, protein kinase A anchoring protein 10, mitochondrial A kinase PPKA anchor protein 10 |
| Synonyms | 1500031L16Rik, A-kinase anchoring protein 10, A kinase anchor protein 10, B130049N18RIK, D-AKAP-2, PRKA10 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AKAP10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Regulator of G protein signaling domain
- protein kinase A binding
- Regulator of G protein signaling (RGS) domain superfamily
- protein binding
Pathways
Biological processes and signaling networks where the AKAP10 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- breast cancer
- gastric adenocarcinoma
- bipolar disorder
- gastric epithelial cancer
- migraines
- arrhythmia
regulated by
- beta-estradiol
- Z-LLL-CHO
- GnRH analog
role in cell
- expression in
- production in
- phosphorylation in
- shortening
- disruption in
- contraction
- relaxation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- Mitochondria
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AKAP10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- protein localization
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- cytosol
- macromolecular complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein kinase A binding