SYNGR2 Gene Summary [Human]
This gene encodes an integral membrane protein containing four transmembrane regions and a C-terminal cytoplasmic tail that is tyrosine phosphorylated. The exact function of this protein is unclear, but studies of a similar rat protein suggest that it may play a role in regulating membrane traffic in non-neuronal cells. The gene belongs to the synaptogyrin gene family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Details
| Type | Protein Coding |
| Official Symbol | SYNGR2 |
| Official Name | synaptogyrin 2 [Source:HGNC Symbol;Acc:HGNC:11499] |
| Ensembl ID | ENSG00000108639 |
| Bio databases IDs | |
| Aliases | synaptogyrin 2, cellugyrin |
| Synonyms | cellugyrin, Clast2, synaptogyrin 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SYNGR2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Membrane-associating domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- vitiligo
- lung carcinoma
- lung carcinoma process
- lichen planus
role in cell
- cell death
- number
- replication in
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- synaptic vesicle membrane
- cellular membrane
- synaptic vesicles
- synaptic-like microvesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SYNGR2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synaptic vesicle membrane organization
- regulated secretory pathway
Cellular Component
Where in the cell the gene product is active
- lipid particle
- extracellular vesicular exosome
- membrane
- neuromuscular junction
- synaptic vesicle membrane
Molecular Function
What the gene product does at the molecular level
- protein binding