TTC3 Gene Summary [Human]
Enables ubiquitin-protein transferase activity. Involved in protein K48-linked ubiquitination and ubiquitin-dependent protein catabolic process. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | TTC3 |
| Official Name | tetratricopeptide repeat domain 3 [Source:HGNC Symbol;Acc:HGNC:12393] |
| Ensembl ID | ENSG00000182670 |
| Bio databases IDs | |
| Aliases | tetratricopeptide repeat domain 3 |
| Synonyms | 2610202A04RIK, AA409221, D16Ium21, D16Ium21e, DCRR1, mKIAA4119, RNF105, tetratricopeptide repeat domain 3, TPRD, TPRDIII |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TTC3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- enzyme
- E3 ubiquitin-protein ligase TTC3/DZIP3 domain
- Ring finger domain
- protein binding
- tetratricopeptide repeat
- Domain of unknown function (DUF4200)
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- behavioral deficit
- Hutchinson-Gilford progeria syndrome
- Down syndrome
- gastric carcinoma
- gastric epithelial cancer
- infection by HIV-1
role in cell
- degradation in
- differentiation
- cytotoxic reaction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- vacuole
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TTC3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein K48-linked ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- Golgi apparatus
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- metal ion binding