ELF2 Gene Summary [Human]
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription, DNA-templated; positive regulation of transcription, DNA-templated; and regulation of transcription by RNA polymerase II. Located in cytosol and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | ELF2 |
| Official Name | E74 like ETS transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:3317] |
| Ensembl ID | ENSG00000109381 |
| Bio databases IDs | |
| Aliases | E74 like ETS transcription factor 2 |
| Synonyms | 2610036A20Rik, A230104O07RIK, E74 like ETS transcription factor 2, E74-like factor 2, EU32, NERF, NERF-1A, NERF-1a,b, NERF-1B, NERF-2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ELF2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- Ets-domain
- transcription activation domain
- protein binding
- sequence-specific DNA binding
- basic domain
- transcription factor activity
- Transcription factor protein N terminal
Pathways
Biological processes and signaling networks where the ELF2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- peripheral T-cell lymphoma
- insomnia
- covid-19 death
- cerebellar ataxia, neuropathy and vestibular areflexia syndrome
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
role in cell
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ELF2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- cell differentiation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity