NCAPG Gene Summary [Human]
This gene encodes a subunit of the condensin complex, which is responsible for the condensation and stabilization of chromosomes during mitosis and meiosis. Phosphorylation of the encoded protein activates the condensin complex. There are pseudogenes for this gene on chromosomes 8 and 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Details
| Type | Protein Coding |
| Official Symbol | NCAPG |
| Official Name | non-SMC condensin I complex subunit G [Source:HGNC Symbol;Acc:HGNC:24304] |
| Ensembl ID | ENSG00000109805 |
| Bio databases IDs | |
| Aliases | non-SMC condensin I complex subunit G, chromosome condensation protein G |
| Synonyms | 5730507H05Rik, CAPG, CHCG, HCAP-G, MFT.M05.13, non-SMC condensin I complex subunit G, non-SMC condensin I complex, subunit G, NY-MEL-3, RGD1562646, YCG1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NCAPG often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Nuclear condensing complex subunits, C-term domain
- protein binding
- HEAT repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung carcinoma
- neoplasia
- tumorigenesis
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- B cell cancer
- cancer
- epithelial neoplasia
- metastasis
role in cell
- expression in
- migration
- proliferation
- apoptosis
- growth
- production in
- quantity
- phosphorylation in
- invasion by
- activity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin fraction
- Cytoplasm
- cytosol
- chromosome
- germinal vesicles
- centromeres
- chromosomal arms
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NCAPG gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- positive regulation of chromosome segregation
- mitotic chromosome condensation
Cellular Component
Where in the cell the gene product is active
- condensed chromosome
- nucleus
- cytoplasm
- membrane
- condensed chromosome, centromeric region
- cytosol
- condensin complex
- condensed nuclear chromosome
Molecular Function
What the gene product does at the molecular level
- protein binding