TNP1 Gene Summary [Human]
Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880; PRM2, MIM 182890) (Luerssen et al., 1990 [PubMed 2249851]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | TNP1 |
| Official Name | transition protein 1 [Source:HGNC Symbol;Acc:HGNC:11951] |
| Ensembl ID | ENSG00000118245 |
| Bio databases IDs | |
| Aliases | transition protein 1, spermatid nuclear transition protein 1 |
| Synonyms | Stp-1, TP1, Transition protein 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TNP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Nuclear transition protein 1
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthenozoospermia
role in cell
- formation
- morphology
- differentiation
- development
- abnormal morphology
- differentiation in
- remodeling
- cell movement
- disassembly
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TNP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatid nucleus elongation
- spermatid development
- sperm chromatin decondensation
- spermatid nucleus differentiation
- sperm chromatin condensation
- nucleosome disassembly
- single strand break repair
- chromatin remodeling
- sperm motility
- negative regulation of transcription, DNA-dependent
- heterochromatin assembly
- positive regulation of protein processing
- sexual reproduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleosome
- male germ cell nucleus
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding