PPP6R3 Gene Summary [Human]
Protein phosphatase regulatory subunits, such as SAPS3, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS3 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010]
Details
| Type | Processed Transcript |
| Official Symbol | PPP6R3 |
| Official Name | protein phosphatase 6 regulatory subunit 3 [Source:HGNC Symbol;Acc:HGNC:1173] |
| Ensembl ID | ENSG00000110075 |
| Bio databases IDs | |
| Aliases | protein phosphatase 6 regulatory subunit 3, sporulation-induced transcript 4-associated protein |
| Synonyms | 4930528G08Rik, 9130026N02Rik, C11orf23, D19Bwg1430e, D19Ertd703e, LOC103694577, mKIAA1558, PP6R3, PPCS3, Ppp6r3-ps1, Pptcs3, protein phosphatase 6 regulatory subunit 3, protein phosphatase 6, regulatory subunit 3, Rel. sporulation-induced transcript 4, RGD1307145, SAP190, SAPL, SAPLa, SAPS3, Saps3-ps1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPP6R3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SIT4 phosphatase-associated protein
- protein phosphatase binding
- protein phosphatase regulator
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPP6R3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of phosphoprotein phosphatase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein phosphatase binding
- protein phosphatase regulator activity