HPX Gene Summary [Human]
This gene encodes a plasma glycoprotein that binds heme with high affinity. The encoded protein is an acute phase protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative stress. [provided by RefSeq, Apr 2009]
Details
| Type | Protein Coding |
| Official Symbol | HPX |
| Official Name | hemopexin [Source:HGNC Symbol;Acc:HGNC:5171] |
| Ensembl ID | ENSG00000110169 |
| Bio databases IDs | |
| Aliases | hemopexin |
| Synonyms | haemo, haemopexin, HEMO, hemopexin, HPXN, HX |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HPX often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hemopexin-like repeats
- HX
- protein binding
- heme binding
- heme transporter
- transporter
Pathways
Biological processes and signaling networks where the HPX gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- hyperlipidemia
- liver cancer
- splenomegaly
- coronary disease
- bladder cancer
- experimental autoimmune encephalomyelitis
- hepatocellular carcinoma
- progressive familial intrahepatic cholestasis type 1
- ovarian cancer
role in cell
- expression in
- activation in
- phosphorylation in
- quantity
- number
- formation
- expansion
- differentiation
- phagocytosis by
- recruitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- organelle lumens
- Nucleus
- endosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HPX gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular iron ion homeostasis
- interferon-gamma-mediated signaling pathway
- positive regulation of humoral immune response mediated by circulating immunoglobulin
- positive regulation of immunoglobulin production
- positive regulation of tyrosine phosphorylation of STAT protein
- heme metabolic process
- positive regulation of interferon-gamma-mediated signaling pathway
- hemoglobin metabolic process
- heme transport
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- endocytic vesicle lumen
- blood microparticle
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- heme transporter activity
- metal ion binding