PARP11 Gene Summary [Human]
Enables NAD+ ADP-ribosyltransferase activity and protein ADP-ribosylase activity. Involved in protein auto-ADP-ribosylation and protein mono-ADP-ribosylation. Located in cytosol; nuclear body; and nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | PARP11 |
| Official Name | poly(ADP-ribose) polymerase family member 11 [Source:HGNC Symbol;Acc:HGNC:1186] |
| Ensembl ID | ENSG00000111224 |
| Bio databases IDs | |
| Aliases | poly(ADP-ribose) polymerase family member 11 |
| Synonyms | 5330431N24Rik, ARTD11, C12orf6, HIN1L, HINL1, LOC683255, MIB006, poly (ADP-ribose) polymerase family, member 11, poly(ADP-ribose) polymerase family member 11, RGD1561791 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PARP11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain in Deltex and TRIP12 homologues
- pentosyltransferase
- NAD ADP-ribosyltransferase
- Poly(ADP-ribose) polymerase catalytic domain
- WWE domain
- enzyme
- protein binding
- ADP_ribosyl
Pathways
Biological processes and signaling networks where the PARP11 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- IFNB1
- histone H3
role in cell
- expression in
- phosphorylation in
- organization
- mitotic entry in
- replication in
- checkpoint recovery in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nuclear pores
- nucleoplasm
- nuclear bodies
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PARP11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nuclear envelope organization
- spermatogenesis
- protein transport
- cell differentiation
- protein auto-ADP-ribosylation
- mRNA transport
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nucleus
- nuclear body
- cytosol
- nucleoplasm
- nuclear pore
Molecular Function
What the gene product does at the molecular level
- nucleotidyltransferase activity
- NAD+ ADP-ribosyltransferase activity