DUSP16 Gene Summary [Human]
This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 2010]
Details
| Type | Protein Coding |
| Official Symbol | DUSP16 |
| Official Name | dual specificity phosphatase 16 [Source:HGNC Symbol;Acc:HGNC:17909] |
| Ensembl ID | ENSG00000111266 |
| Bio databases IDs | |
| Aliases | dual specificity phosphatase 16, MAPK phosphatase-7 |
| Synonyms | 3830417M17Rik, D6Ertd213e, dual specificity phosphatase 16, MKP-7, Mkpm |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DUSP16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- protein-tyrosine-phoshatase
- phosphoprotein phosphatase
- Rhodanese Homology Domain
- mitogen-activated protein kinase p38 binding
- JUN kinase binding
- protein binding
- Rhodanese-like domain
- PTP_DSP_cys
- RHOD
- Protein tyrosine phosphatase, catalytic domain motif
- Dual specificity phosphatase, catalytic domain
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- protein phosphatase
- phosphatase
Pathways
Biological processes and signaling networks where the DUSP16 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- restless legs syndrome
- chronic lymphocytic leukemia
- inflammatory bowel disease
- pelvic organ prolapse
- ulcerative colitis
- idiopathic scoliosis
- infection by HIV-1
role in cell
- expression in
- quantity
- phosphorylation in
- mitochondrial respiration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DUSP16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of MAPK cascade
- dephosphorylation
- peptidyl-tyrosine dephosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytoplasmic vesicle
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphoprotein phosphatase activity
- protein binding
- mitogen-activated protein kinase p38 binding
- MAP kinase tyrosine phosphatase activity
- protein tyrosine/threonine phosphatase activity
- phosphatase activity
- JUN kinase binding
- mitogen-activated protein kinase binding
- MAP kinase tyrosine/serine/threonine phosphatase activity
- myosin phosphatase activity