BORA Gene Summary [Human]
BORA is an activator of the protein kinase Aurora A (AURKA; MIM 603072), which is required for centrosome maturation, spindle assembly, and asymmetric protein localization during mitosis (Hutterer et al., 2006 [PubMed 16890155]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | BORA |
| Official Name | BORA aurora kinase A activator [Source:HGNC Symbol;Acc:HGNC:24724] |
| Ensembl ID | ENSG00000136122 |
| Bio databases IDs | |
| Aliases | BORA aurora kinase A activator |
| Synonyms | 6720463M24Rik, AI317232, BORA aurora kinase A activator, bora, aurora kinase A activator, C13orf34, RGD1309522 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BORA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein aurora borealis N-terminus
- protein kinase binding
- protein binding
Pathways
Biological processes and signaling networks where the BORA gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- meiotic spindles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BORA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- regulation of protein localization
- regulation of mitosis
- activation of protein kinase activity
- regulation of mitotic spindle organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- meiotic spindle
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding