SPRING1 Gene Summary [Human]
Involved in positive regulation of SREBP signaling pathway. Located in Golgi membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SPRING1 |
| Official Name | SREBF pathway regulator in golgi 1 [Source:HGNC Symbol;Acc:HGNC:26128] |
| Ensembl ID | ENSG00000111412 |
| Bio databases IDs | |
| Aliases | SREBF pathway regulator in golgi 1, SREBP regulating gene, partner of site-1 protease |
| Synonyms | 2410131K14Rik, C12orf49, FLJ21415, LUR1, POST1, RGD1562310, SPRING, SREBF pathway regulator in golgi 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SPRING1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SREBP regulating gene protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- preeclampsia
- neuroticism
- asthma
- hepatic steatosis
role in cell
- expression in
- biosynthesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SPRING1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of SREBP-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- protein binding