HMGCS1 Gene Summary [Human]
Enables protein homodimerization activity. Predicted to be involved in acetyl-CoA metabolic process and farnesyl diphosphate biosynthetic process, mevalonate pathway. Predicted to be located in cytoplasm. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | HMGCS1 |
| Official Name | 3-hydroxy-3-methylglutaryl-CoA synthase 1 [Source:HGNC Symbol;Acc:HGNC:5007] |
| Ensembl ID | ENSG00000112972 |
| Bio databases IDs | |
| Aliases | 3-hydroxy-3-methylglutaryl-CoA synthase 1, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase |
| Synonyms | 3-hydroxy-3-methylglutaryl-CoA synthase 1, 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1, B130032C06Rik, HMGCS, HMGS, Hydroxymethylglutaryl-CoA synthase, cytoplasmic, MGC36662 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HMGCS1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cond_enzymes
- 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade
- binding protein
- 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
- hydroxymethylglutaryl-CoA synthase
- protein homodimerization
- isomerase
- enzyme
- protein binding
- Hydroxymethylglutaryl-coenzyme A synthase C terminal
Pathways
Biological processes and signaling networks where the HMGCS1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- neoplasia
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- organismal death
- rigid spine syndrome
- preeclampsia
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
role in cell
- expression in
- proliferation
- morphology
- cell death
- invasion by
- survival
- growth
- molecular cleavage in
- bacterial burden
- regrowth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HMGCS1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- farnesyl diphosphate biosynthetic process, mevalonate pathway
- acetyl-CoA metabolic process
- lipid metabolic process
- cholesterol biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- hydroxymethylglutaryl-CoA synthase activity