UBN1 Gene Summary [Human]
Cellular senescence is a hallmark of tumor suppression and tissue aging. Senescent cells contain domains of heterochromatin, called senescence-associated heterochromatin foci (SAHF), that repress proliferation-promoting genes. The protein encoded by this gene binds to proliferation-promoting genes and is required for SAHF formation, enhancing methylation of histone H3. [provided by RefSeq, Oct 2016]
Details
| Type | Protein Coding |
| Official Symbol | UBN1 |
| Official Name | ubinuclein 1 [Source:HGNC Symbol;Acc:HGNC:12506] |
| Ensembl ID | ENSG00000118900 |
| Bio databases IDs | |
| Aliases | ubinuclein 1 |
| Synonyms | 1110029L11Rik, 2610108L02Rik, ubinuclein 1, VT, VT4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UBN1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Ubinuclein conserved middle domain
- hpc2p-related domain
- transcription factor binding
- protein binding
- HPC2 and ubinuclein domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- centrosome
- nucleoplasm
- nuclear bodies
- nuclear speckles
- tight junctions
- PML nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human UBN1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin organization
- nucleosome assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- tight junction
- nuclear body
- PML body
- centriolar satellite
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding