SNX3 Gene Summary [Human]
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like most family members. This protein interacts with phosphatidylinositol-3-phosphate, and is involved in protein trafficking. A pseudogene of this gene is present on the sex chromosomes. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
Details
| Type | Protein Coding |
| Official Symbol | SNX3 |
| Official Name | sorting nexin 3 [Source:HGNC Symbol;Acc:HGNC:11174] |
| Ensembl ID | ENSG00000112335 |
| Bio databases IDs | |
| Aliases | sorting nexin 3 |
| Synonyms | Grd19, MCOPS8, SDP3, sorting nexin 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SNX3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- protein phosphatase binding
- The Phox Homology domain, a phosphoinositide binding module
- protein binding
- phosphatidylinositol binding
- PX domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- outgrowth
- morphology
- formation
- formation in
- degradation in
- phagocytosis by
- development
- retention in
- invagination
- swelling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cell periphery
- cytosol
- endosomal membrane
- early endosomes
- postsynaptic density
- clathrin-coated vesicles
- phagosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SNX3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein to membrane docking
- protein transport
- negative regulation of protein catabolic process
- negative regulation of protein transport
- response to bacterium
- negative regulation of viral entry into host cell
- negative regulation of early endosome to late endosome transport
- intralumenal vesicle formation
- membrane invagination
- positive regulation of neuron projection development
- late endosome to Golgi transport
- regulation of Wnt receptor signaling pathway
- endocytic recycling
- negative regulation of phagocytosis
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- early endosome
- early phagosome
- extracellular vesicular exosome
- cytoplasm
- retromer complex
- cytosol
- endosome membrane
- clathrin-coated vesicle
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-4-phosphate binding
- protein phosphatase binding
- protein binding
- phosphatidylinositol-5-phosphate binding
- phosphatidylinositol-3,5-bisphosphate binding
- phosphatidylinositol-3-phosphate binding