Snx3 Gene Summary [Mouse]
Enables phosphatidylinositol phosphate binding activity. Involved in positive regulation of neuron projection development. Acts upstream of or within several processes, including hemoglobin biosynthetic process; regulation of intracellular protein transport; and transferrin transport. Predicted to be located in cytoplasmic vesicle and cytosol. Predicted to be part of retromer complex. Predicted to be active in early endosome membrane. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and hemolymphoid system. Orthologous to human SNX3 (sorting nexin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Snx3 |
| Official Name | sorting nexin 3 [Source:MGI Symbol;Acc:MGI:1860188] |
| Ensembl ID | ENSMUSG00000019804 |
| Bio databases IDs | |
| Aliases | sorting nexin 3 |
| Synonyms | Grd19, MCOPS8, SDP3, sorting nexin 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Snx3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- protein phosphatase binding
- The Phox Homology domain, a phosphoinositide binding module
- protein binding
- phosphatidylinositol binding
- PX domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- outgrowth
- morphology
- formation
- formation in
- degradation in
- phagocytosis by
- development
- retention in
- invagination
- swelling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cell periphery
- cytosol
- endosomal membrane
- early endosomes
- postsynaptic density
- clathrin-coated vesicles
- phagosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Snx3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein to membrane docking
- protein transport
- negative regulation of protein catabolic process
- negative regulation of protein transport
- response to bacterium
- negative regulation of viral entry into host cell
- negative regulation of early endosome to late endosome transport
- intralumenal vesicle formation
- membrane invagination
- positive regulation of neuron projection development
- late endosome to Golgi transport
- regulation of Wnt receptor signaling pathway
- endocytic recycling
- negative regulation of phagocytosis
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- early endosome
- early phagosome
- extracellular vesicular exosome
- cytoplasm
- retromer complex
- cytosol
- endosome membrane
- clathrin-coated vesicle
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-4-phosphate binding
- protein phosphatase binding
- protein binding
- phosphatidylinositol-5-phosphate binding
- phosphatidylinositol-3,5-bisphosphate binding
- phosphatidylinositol-3-phosphate binding