CPEB2 Gene Summary [Human]
The protein encoded by this gene is highly similar to cytoplasmic polyadenylation element binding protein (CPEB), an mRNA-binding protein that regulates cytoplasmic polyadenylation of mRNA as a trans factor in oogenesis and spermatogenesis. Studies of the similar gene in mice suggested a possible role of this protein in transcriptionally inactive haploid spermatids. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CPEB2 |
| Official Name | cytoplasmic polyadenylation element binding protein 2 [Source:HGNC Symbol;Acc:HGNC:21745] |
| Ensembl ID | ENSG00000137449 |
| Bio databases IDs | |
| Aliases | cytoplasmic polyadenylation element binding protein 2 |
| Synonyms | A630055H10Rik, CPE-BP2, cytoplasmic polyadenylation element binding protein 2, hCPEB-2, Polyadenyl 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CPEB2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- Cytoplasmic polyadenylation element-binding protein ZZ domain
- mRNA 3' UTR binding
- GTPase inhibitor
- RNA recognition motif
- nucleic acid binding translation repressor
- ribosome binding
- protein binding
- poly-pyrimidine tract binding
- ribosomal large subunit binding
- translation regulator
- ribosomal small subunit binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- bronchoconstriction
- respiratory failure
- neoplasia
- epithelial cancer
- plasma cell myeloma
- metastasis
- HER2-positive breast cancer
- glioblastoma
- glioblastoma cancer
role in cell
- expression in
- apoptosis
- proliferation
- abnormal morphology
- anoikis
- response by
- stabilization in
- translation in
- metastatic potential
- G1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- ribosome
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CPEB2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to insulin stimulus
- cellular response to hypoxia
- negative regulation of cytoplasmic translation
- negative regulation of cytoplasmic translational elongation
- translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- synapse
- neuron projection
Molecular Function
What the gene product does at the molecular level
- RNA binding
- GTPase inhibitor activity
- mRNA 3'-UTR AU-rich region binding
- ribosome binding
- ribosomal small subunit binding
- translation repressor activity, nucleic acid binding
- ribosomal large subunit binding
- translation factor activity, nucleic acid binding
- mRNA 3'-UTR binding