Tars Gene Summary [Mouse]
Enables threonine-tRNA ligase activity. Involved in threonyl-tRNA aminoacylation. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; integumental system; liver; and sensory organ. Human ortholog(s) of this gene implicated in nonphotosensitive trichothiodystrophy 7. Orthologous to human TARS1 (threonyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Tars |
| Official Name | threonyl-tRNA synthetase [Source:MGI Symbol;Acc:MGI:106314] |
| Ensembl ID | ENSMUSG00000022241 |
| Bio databases IDs | |
| Aliases | threonyl-tRNA synthetase |
| Synonyms | D15Wsu59e, PL-7, TARS, threonyl-tRNA synthetase 1, ThrRS, TRAS, TTD7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tars often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HGTP_anticodon
- threonyl-tRNA synthetase
- TGS domain
- class_II_aaRS-like_core
- ATP binding
- enzyme
- protein binding
- identical protein binding
- threonine-tRNA ligase
- tRNA synthetase class II core domain (G, H, P, S and T)
- Anticodon binding domain
- zinc ion binding
- Ubl1_cv_Nsp3_N-like
- Threonyl and Alanyl tRNA synthetase second additional domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- detergent resistant lipid raft fraction
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tars gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- threonyl-tRNA aminoacylation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- zinc ion binding
- identical protein binding
- protein binding
- threonine-tRNA ligase activity
- tRNA binding