CSPG5 Gene Summary [Human]
The protein encoded by this gene is a proteoglycan that may function as a neural growth and differentiation factor. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Details
| Type | Protein Coding |
| Official Symbol | CSPG5 |
| Official Name | chondroitin sulfate proteoglycan 5 [Source:HGNC Symbol;Acc:HGNC:2467] |
| Ensembl ID | ENSG00000114646 |
| Bio databases IDs | |
| Aliases | chondroitin sulfate proteoglycan 5, neuroglycan C |
| Synonyms | Caleb, chondroitin sulfate proteoglycan 5, chondroitin sulphate proteoglycan 5, NGC |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CSPG5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytoplasmic domain
- Neural chondroitin sulphate proteoglycan cytoplasmic domain
- ectodomain
- Chondroitin sulphate attachment domain
- protein binding
- membrane-proximal domain
- acidic domain
- EGF-like domain
- growth factor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- migration
- cell spreading
- outgrowth
- exocytosis
- organization
- paired-pulse facilitation
- attachment
- transmission
- long term synaptic depression
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- raft fractions
- Golgi lumen
- glutaminergic synapse
- cell pole
- perinuclear region
- membrane surface
- cellular membrane
- Plasma Membrane
- vesicles
- Golgi Apparatus
- endoplasmic reticulum membrane
- postsynaptic membrane
- Golgi membrane
- lysosomal compartment
- spindle pole
- neurites
- synapse
- membrane rafts
- perikaryon
- dendrites
- Golgi vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CSPG5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoskeleton organization
- signal transduction
- intracellular transport
- nervous system development
- regulation of synaptic vesicle exocytosis
- positive regulation of substrate adhesion-dependent cell spreading
- axon regeneration
- cell projection morphogenesis
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
- Golgi apparatus
- lysosomal lumen
- synapse
- Golgi lumen
- extracellular region
- plasma membrane
- cell surface
- endoplasmic reticulum membrane
- postsynaptic membrane
- membrane
- Golgi-associated vesicle membrane
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding