TRAT1
TRAT1 Gene Summary
Predicted to enable transmembrane receptor protein tyrosine kinase adaptor activity. Acts upstream of or within negative regulation of receptor recycling; negative regulation of transport; and positive regulation of signal transduction. Located in centriolar satellite; mitotic spindle; and plasma membrane. Part of T cell receptor complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TRAT1 |
| Official Name | T cell receptor associated transmembrane adaptor 1 [Source:HGNC Symbol;Acc:HGNC:30698] |
| Ensembl ID | ENSG00000163519 |
| Bio databases IDs | |
| Aliases | T cell receptor associated transmembrane adaptor 1 |
| Synonyms | C030046M14Rik,HSPC062,pp29/30,T cell receptor associated transmembrane adaptor 1,TCRIM,TRIM |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- SHP2-interacting transmembrane adaptor protein, SIT
- extracellular domain
- transmembrane domain
- intracellular domain
- protein binding
- transmembrane receptor protein tyrosine kinase adaptor protein
Pathways
Biological processes and signaling networks where the TRAT1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- SSR3
- PLXDC2
- CD247
- IFT22
- GRB2
- PI3K (complex)
- FAM136A
- STMN3
- SPMIP9
- PCBP4
disease
- autoimmune thyroid disease
- androgenic alopecia
- septic shock
- hypoplasia
- diabetic nephropathy
regulated by
- B lymphocytes
- GATA2
- CREBBP
- EP300
- ZAP70
regulates
- p38 MAPK
- Ca2+
- ERK1/2
- CD5
- TRB
- HAMP
- receptor
- CD3E
- TRA
- Cd69
role in cell
- apoptosis
- activation in
- expression in
- cell viability
- migration
- development
- number
- invasion by
- response
- positive selection
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- perinuclear region
- centrosome
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the TRAT1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- positive regulation of calcium-mediated signaling
- positive regulation of T cell receptor signaling pathway
- cellular defense response
- negative regulation of receptor recycling
- signal transduction
- negative regulation of transport
- transmembrane receptor protein tyrosine kinase signaling pathway
- adaptive immune response
CELLULAR COMPONENT
Where in the cell the gene product is active
- mitotic spindle
- centriolar satellite
- T cell receptor complex
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- transmembrane receptor protein tyrosine kinase adaptor activity